Welcome to the Bridges Lab

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We are interested in the factors which cause obesity, the mechanisms by which this happens and how interventions in this pathway can alleviate obesity or its associated diseases. Our group uses a variety of model systems including cell culture, yeast, flies and mice to understand the signaling and metabolic pathways which are involved in these processes. We then use modern molecular biology, genetic and pharmacological tools to manipulate and learn more about the physiology of obesity.

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Recent Publications

Dave Bridges and Alan Saltiel. Phosphoinositides: Key Modulators of Energy Metabolism 2014. Biochimica and Biophysica Acta - Molecular and Cell Biology of Lipids In Press: Full Text Details.
Izzy Hatfield, Innocence Harvey, Lawrence Reiter and Dave Bridges. The role of TORC1 in muscle development in Drosophila. 2014. bioRxiv 11(2):010991 Full Text Details. Preprint
Qingming Dong, Francesco Giorgianni, Xiong Deng, Sarka Beranova-Giorgianni, Dave Bridges, Edwards Park, Rajendra Raghow and Marshal Elam. Phosphorylation of Sterol Regulatory Element Binding Protein-1a by Protein Kinase A (PKA) Regulates Transcriptional Activity 2014. Biochemical and Biophysical Research Communications 449(4):449-54 Full Text Details.
Anne Morrow, Mohsen Amir Alipour, Dave Bridges, Zemin Yao, Alan Saltiel and Jonathan Lee. The lipid kinase PI4KIIIbeta is highly expressed in breast tumours and activates Akt in cooperation with Rab11a. 2014. Molecular Cancer Research Full Text Details.
Natsuko JIn, Kai Mao, Yui Jin, Gela Tevadze, Emily Kauffman, Sujin Park, Dave Bridges, Robbie Loewith, Alan Saltiel, Daniel Klionsky and Lois Weisman. Roles for PI(3,5)P2 in nutrient sensing through TORC1 2014. Molecular Biology of the Cell 25(7):1171-85 Full Text Details.

Recent Journal Clubs

Andrew Shin, Martin Fasshauer, Nika Filatova, Linus Grundell, Elizabeth Zielinski, Jian-Ying Zhou, Thomas Scherer, Claudia Lindtner, Amanda Lapworth, Olga Ilkayeva, Uwe Knippschild, Anna Wolf, Ludger Shedja, Kevin Grove, Richard Smith, Wei-Jun Qian, Chrisopher Lynch, Christopher Newgard and Christophe Buettner. Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism. 2014. Cell metabolism S1550-4131(14):00400-8 Full Text Our Thoughts Details.
O. Nelson, Jingxiang Huang, Heiko Jansen, Elizabeth Galbreath, Kurt Morgenstern, Jamie Gehring, Kimberly Rigano, Jae Lee, Jianhua Gong, Adam Shaywitz, Chantal Vella, Charles Robbins and Kevin Corbit. Grizzly Bears Exhibit Augmented Insulin Sensitivity while Obese Prior to a Reversible Insulin Resistance during Hibernation 2014. Cell Metabolism 20(2):376-82 Full Text Our Thoughts Details.
Robert Koza, Larissa Nikonova, Jessica Hogan, Jong-Seop Rim, Tamra Mendoza, Christopher Faulk, Jihad Skaf and Leslie Kozak. Changes in gene expression foreshadow diet-induced obesity in genetically identical mice. 2006. PLOS Genetics 2(5):e81 Full Text Our Thoughts Details.
Xiaoyuan Xu, Ambar Grijalva, Alicja Skowronski, Marco van Eijk, Mireille J Serlie and Anthony Ferrante. Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation. 2014. Cell metabolism 18(6):816-30 Full Text Our Thoughts Details.
Hui Zhang, Jingxiang Huang, Katrin Düvel, Bernard Boback, Shulin Wu, Rachel Squillace, Chin-Lee Wu and Brendan Manning. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. 2009. PLOS One 4(7):e6189 Full Text Our Thoughts Details.