Glucocorticoid-Induced Metabolic Disturbances are Exacerbated in Obesity

, Erin Stephenson, , Quynh Tran, Irit Hochberg, Nathan Qi and

bioRxiv 2017. This work is a preprint and is currently under review.

Abstract

Obesity and chronically elevated glucocorticoids result in similar co-morbidities, but the e ect of a combination of these ailments on metabolic outcomes is unclear. Measures of glucose homeostasis and markers of hepatic lipid accumulation were assessed to determine whether obesity exaggerated the e ffects of dexamethasone induced metabolic disturbances. The combination of obesity and glucocorticoids resulted in hepatic steatosis and synergistic impairments in insulin sensitivity and this was matched with synergistic elevations in markers of lipolysis. These findings suggest lipolysis may be a key player in glucocorticoid-induced insulin resistance and fatty liver in people with obesity.

Author Contributions

Innocence Harvey

Conceptualization Formal Analysis Investigation Methodology Visualization Writing - Original Draft Writing - Review and Editing

Erin Stephenson

Investigation Methodology Writing - Review and Editing

JeAnna Redd

Data Curation Investigation

Quynh Tran

Validation Formal Analysis Methodology

Irit Hochberg

Investigation Writing - Review and Editing

Nathan Qi

Investigation Methodology

Dave Bridges

Conceptualization Data Curation Formal Analysis Funding Acquisition Project Administration Validation Visualization Writing - Review and Editing

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