The Target of Rapamycin Complex I has been implicated in the regulation of aging and lifespan in many eukaryotic organisms ranging from yeast to humans. We are interested in how aberrant nutrient sensing, and TORC1 in specific, causes delayed or accelerated aging in model organisms.
To test this we are using mice, flies and yeast, we are studying how this complex is regulated during aging, and how manipulation of this complex alters lifespan and aging related phenotypes. We generate genetically modified or pharmacological approaches using these animals where these pathways are activated or repressed. We then test for changes in lifespan and normal function in these organisms. We are particularly interested in determining the molecular mechanisms and potential reversibility of these changes associated with aging.